Exosmart Autologous Exosomes

Product Info

Autologous Exosomes via Ultrafiltration

Ultrafiltration technology enhances the release of exosomes through controlled mechanical stimulation of platelets. This method has been highlighted in multiple studies as an effective approach for improving both the purity and concentration of exosomes during the separation and refinement process.

Why Choose Exosomes Over PRP?

Platelet-derived exosomes offer greater stability and reduced immunogenicity compared to traditional PRP. Their small size and biological activity allow them to function efficiently in intercellular communication and tissue regeneration. Increasingly, exosomes are recognised as key mediators responsible for many of the physiological and regenerative effects traditionally attributed to PRP.

Exosmart™ is a CE-MDR certified Class IIa medical device designed to advance regenerative medicine through its patented ultrafiltration technology. Utilizing a 15 kDa molecular weight cut-off membrane, Exosmart™ converts 30 mL of plasma (derived from 60 mL of whole blood) into 6–7 mL of highly concentrated therapeutic product, delivering up to 30 trillion exosomes per millilitre—up to 136 times higher than established reference standards.

Validated in accordance with MISEV2023 guidelines, Exosmart™ demonstrates exceptional purity, including 93.2% CD9-positive markers and a 47% increase in PDGF-bb growth factor levels. The final concentrate contains a powerful combination of exosomes (30–150 nm), platelets (70–95% recovery rate), key growth factors such as VEGF, TGF-β, and FGF, along with cytokines and plasma proteins. These components work synergistically to regulate inflammation, stimulate stem cell activity, enhance angiogenesis, and accelerate tissue regeneration across a broad range of clinical applications.

Supported by strong safety data, including zero adverse events reported in clinical trials and a 100% processing success rate, Exosmart™ elevates routine procedures into advanced regenerative therapies. From orthopaedics and aesthetics to wound care and surgical applications, it provides standardized, reproducible outcomes—often achieving in a single session results that traditionally require multiple treatments.

FAQ

How is the exosmart product different from standard PRP?

It is fundamentally superior for two key reasons:

Comprehensiveness - Conventional PRP preparation discards platelet-poor plasma (PPP), despite it containing billions of valuable exosomes. In contrast, exosmart™ processes the entire plasma volume—both PRP and PPP—ensuring the full therapeutic spectrum is captured and concentrated.

Consistency - The automated ultrafiltration system eliminates the manual variability often associated with traditional PRP protocols, producing a standardized, high-quality concentrate with reliable results every time.

How many treatment areas does one kit cover?

One exosmart kit produces 6-7 mL of concentrate, which is typically sufficient for treating a large area like the full face, the scalp for hair restoration, or a major joint like the knee.

Why is this better than using allogeneic (donor) exosomes?

Safety and practicality. exosmart uses the patient’s own blood (autologous), which eliminates all risk of immune rejection or pathogen transmission. Allogeneic products carry this inherent risk and are subject to much stricter regulations, often limiting them to topical use only. Our system provides a safer, fully compliant solution at the point of care.